Iran has struck Israel with barrages of missiles, a day after an Israeli onslaught against its nuclear and military facilities killed top generals and scientists.

Iranian missiles have targeted sites across Israel, killing at least three people and injuring dozens, in retaliation for continuing Israeli attacks on Iran.

Iran called on its citizens to unite in defence of the country as Israeli Prime Minister Benjamin Netanyahu urged them to rise up against their government.

Air raid sirens and explosions rang out across Israel through the night, with many residents holed up in bomb shelters until home defence commanders stood down alerts.

Israel said dozens of missiles – some intercepted – had been fired in the latest salvoes from Iran, with images of the city of Ramat Gan near Tel Aviv showing blown-out buildings, destroyed vehicles and streets strewn with debris.

Iran’s Islamic Revolutionary Guard Corps said they attacked dozens of targets in Israel.

Iran’s missile barrages came in response to intense Israeli strikes on Friday that killed several top Iranian generals and most of the senior leadership of the Revolutionary Guards’ air arm.